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The splints were not disturbed for about a fortnight, when,- again under an anaesthetic, they were readjusted, the flexion of the wrist was reduced, and the extension at the metacarpal-phalangeal joints was increased, the splints being anaesthetised, and the fingers and wrist were further manipulated, then fixed up again with the wrist still flexed, and the fingers and wrist freely manipulated, the splints being then reapplied, with the contracture almost fully corrected. These organisms, acting as obligate parasites, must be grown on suitable animal tissues.